A recently published study suggests that integrating CBD into denture materials may help prevent oral infections. The research, which appeared last month in the journal Molecules and backed by government funding, indicates that incorporating CBD into dentures could provide an antibiotic-free method to reduce plaque buildup and improve oral hygiene.
To explore this possibility, scientists infused CBD into polymethyl methacrylate (PMMA), a plastic commonly used in dentures due to its durability and aesthetic appeal. They then evaluated its antimicrobial effects against three bacteria: Streptococcus agalactiae, Escherichia coli, and Staphylococcus aureus.
Findings revealed that CBD-coated dentures were highly effective in killing Gram-positive bacteria. While the coating did not eliminate free-floating Gram-negative bacteria, it successfully eradicated bacterial biofilms.
The study reported a remarkable 99% decrease in biofilm growth for Gram-negative and Gram-positive bacteria on CBD-treated PMMA compared to the standard material. Researchers noted that CBD caused bacterial cell walls to break down and be destroyed.
In certain instances, the contrast between normal and CBD-infused PMMA was striking. For instance, S. agalactiae growth was 10,000 times higher on regular PMMA than on the CBD-coated version. The research also documented a 99% drop in E. coli and S. aureus biofilms and an even greater 99.99% decrease in S. agalactiae biofilms.
One aspect requiring further examination is how to develop coatings that allow for a controlled and prolonged release of CBD to maximize its ability to combat bacteria over time. The researchers observed that CBD released rapidly within the first 12 hours before stabilizing and dispersing gradually in a controlled environment.
Another area for future investigation is why CBD coatings effectively eradicated biofilms but did not affect free-floating planktonic bacteria of the same species. The researchers suggest further research into the genetic mechanisms behind biofilm formation and maintenance, as well as the role of CBD in disrupting bacterial adhesion to surfaces.
These findings align with separate research that explored CBD’s antibacterial effects in other contexts.
One study found that CBD could help treat bacterial vaginosis by weakening Gardnerella vaginalis biofilms, which can disrupt the microbial balance in the vagina. Another study, published in Pharmaceuticals, suggested that CBD might have wound-healing and anti-aging properties, making it a valuable addition to skincare products.
As research into CBD’s medical applications continues, these studies highlight its potential as a natural antibacterial agent that could revolutionize dental and healthcare treatments.
These studies funded by the federal government are helping to confirm what is behind the popularity of marijuana brands and the mushrooming of ancillary enterprises like Innovative Industrial Properties Inc. (NYSE: IIPR) that have been established to address the niche needs of companies dealing directly in marijuana products.
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